Bryson-Richardson Research Group



A transgenic zebrafish model of hepatocyte function in human Z α1-antitrypsin deficiency

E Yip, A Giousoh, B Wilding, MD Prakash, C Williams, H Verkade, RJ Bryson-Richardson, PI Bird,

Biological Chemistry

Metformin rescues muscle function in BAG3 myofibrillar myopathy models

AA Ruparelia, EA McKaige, C Williams, KE Schulze, M Fuchs, V Oorschot, E Lacene, M Mirella, EC Baxter, Y Torrente, G Ramm, T Stojkovic, JN Lavoie, RJ Bryson-Richardson

bioRxiv, 574806

Linking life‐history theory and metabolic theory explains the offspring size‐temperature relationship

AK Pettersen, CR White, RJ Bryson‐Richardson, DJ Marshall

Ecology letters 22 (3), 518-526


Recent advances in understanding congenital myopathies

G Ravenscroft, RJ Bryson-Richardson, KJ Nowak, NG Laing

F1000Research 7

Testing of therapies in a novel nebulin nemaline myopathy model demonstrate a lack of efficacy

Sztal TE, McKaige EA, Williams C, Oorschot V, Ramm G, Bryson-Richardson RJ.

Acta Neuropathol Commun 6:40

L-tyrosine supplementation does not ameliorate skeletal muscle dysfunction in zebrafish and mouse models of dominant skeletal muscle α-actin nemaline myopathy

AM Messineo, C Gineste, TE Sztal, EL McNamara, C Vilmen, AC Ogier, D Hahne, D Bendahan, NG Laing, RJ Bryson-Richardson, J Gondin, KJ Nowak

Scientific reports 8 (1), 11490

The role of ADHD associated genes in neurodevelopment

Dark C, Homman-Ludiye J, Bryson-Richardson RJ.

Dev Biol 438 (2), 762-772

Does the cost of development scale allometrically with offspring size?

AK Pettersen, CR White, RJ Bryson‐Richardson, DJ Marshall

Functional ecology 32 (3), 762-772

Genetic compensation triggered by actin mutation prevents the muscle damage caused by loss of actin protein

Sztal TE, McKaige EA, Williams C, Ruparelia AA, Bryson-Richardson RJ.

PLoS Genet. 2018 Feb 8;14(2):e1007212

Advances in the Understanding of Skeletal Myopathies from Zebrafish Models

EC Baxter, RJ Bryson-Richardson

chapter in Zebrafish, Medaka, and Other Small Fishes, 151-183

234th ENMC International Workshop: Chaperone dysfunction in muscle disease Naarden, The Netherlands, 8–10 December 2017

CC Weihl, B Udd, M Hanna, A Ben-Zvi, T Blaettler, RJ Bryson-Richardson, S Carra, M Dimachkie, A Findlay, L Greensmith, S Greenspan, J Hohfeld, PH Jonson, H Kampinga, L Larsson, W Linke, G Lynch, P Machado, L Orlando, I Richard, A Roos, J Sarparanta, V Timmerman, L Zah

Neuromuscular Disorders 28 (12), 1022-1030



Analysis of RNA Expression in Adult Zebrafish Skeletal Muscle

Sztal TE, Currie PD, Bryson-Richardson RJ.

Methods Mol Biol. 2017;1668:27-35.

Production of zebrafish cardiospheres and cardiac progenitor cells in vitro and three-dimensional culture of adult zebrafish cardiac tissue in scaffolds

Zeng WR, Beh SJ, Bryson-Richardson RJ, Doran PM.

Biotechnol Bioeng. 2017 Sep;114(9):2142-2148.

Genome-wide identification of conserved intronic non-coding sequences using a Bayesian segmentation approach  

Algama M, Tasker E, Williams C, Parslow AC, Bryson-Richardson RJ, Keith JM

BMC Genomics 18:259


Using touch-evoked response and locomotion assays to assess muscle performance and function in zebrafish

Sztal TE, Ruparelia AA, Williams C, Bryson-Richardson RJ

J Vis Exp 2016 Oct 31 (116)

Variants in the Oxidoreductase PYROXD1 Cause Early-Onset Myopathy with Internalized Nuclei and Myofibrillar Disorganization

O’Grady G, Best A, Sztal TE, Schartner V, Sanjuan-Vazquez M, Donkervoort M, Neto OA, Sutton RB, Ilkovski B, Romero NB, Stojkovic T, Dastgir J, Waddell LB, Boland A, Hu Y, Williams C, Ruparelia AA, Maisonobe T, Peduto AJ, Reddel SW, Lek M, Tukiainen T, Cummings BB, Joshi H, Nectoux J, Brammah S, Deleuze JF, Oorschot V, Ramm G, Ardicli D, Nowak KJ, Talim B, Topaloglu H, Laing NG, North KN, MacArthur DG, Friant S, Clarke NF, Bryson-Richardson RJ, Bönnemann CG, Laporte J, Cooper ST

Am J Hum Genet. 99(5):1086-1105.

Filamin C is a highly dynamic protein associated with fast repair of myofibrillar microdamage

Leber Y, Ruparelia AA, Kirfel G, van der Ven PF, Hoffmann B, Merkel R, Bryson-Richardson RJ, Fürst DO

Hum Mol Genet. 25(13):2776-2788

The Driving Mechanism for Unidirectional Blood Flow in the Tubular Embryonic Heart

Kozlovsky P, Bryson-Richardson RJ, Jaffa AJ, Rosenfeld M, Elad D

AnnBiomed Eng. 2016 Apr 25. 44(10):3069-83

FLNC myofibrillar myopathy results from impaired autophagy and protein insufficiency

Ruparelia AA, Oorschot V, Ramm G, Bryson-Richardson RJ

Hum Mol Genet 25(11):2131-2142

Guidelines for the use and interpretation of assays for monitoring autophagy

DJ Klionsky, K Abdelmohsen, A Abe, MJ Abedin, H Abeliovich,… Bryson-Richardson RJ, ….. et al.,

Autophagy 12 (1) 1-222


Zebrafish models for nemaline myopathy reveal a spectrum of nemaline bodies contributing to reduced muscle function

Sztal TE, Zhao M, Williams C, Oorschot V, Parslow AC, Giousoh A, Yuen M, Hall TE, Costin A, Ramm G, Bird PI, Busch-Nentwich EM, Stemple DL, Currie PD, Cooper ST, Laing NG, Nowak KJ, Bryson-Richardson RJ

Acta Neuropathol 130 (3) 389-406

Bone morphogenetic protein/retinoic acid inducible neural-specific protein (brinp) expression during Danio rerio development

Giousoh A, Vaz R, Bryson-Richardson RJ, Whisstock JC, Verkade H, Bird PI

Gene Exp Patterns 18 (1-2) 37-43

Comparison of different numerical treatments for x-ray phase tomography of soft tissue from differential phase projections

Pelliccia D, Vaz R, Svalbe I, Morgan KS, Marathe S, Xiao X, Assoufid L, Anderson RA, Topczewski J, Bryson-Richardson RJ

Phys. Med. Biol. 60 (8) 365


Immuno correlative light and electron microscopy on Tokuyasu cryosections

Oorschot VM, Sztal TE, Bryson-Richardson RJ, Ramm G

Methods Cell Biol 124:241-57

Zebrafish models of BAG3 myofibrillar myopathy suggest a toxic gain of function leading to BAG3 insufficiency

Ruparelia AA, Oorschot V, Vaz R, Ramm G, Bryson-Richardson RJ

Acta Neuropathol 128 (6) 821-833

Sample Drift Correction Following 4D Confocal Time-lapse Imaging

Parslow AC, Cardona A, Bryson-Richardson RJ

J Vis Exp. 2014 Apr 12;(86)

The quail anatomy portal

Ruparelia AA, Simkin JE, Salgado D, Newgreen DF, Martins GG, Bryson-Richardson RJ

Database 2014(0):bau028.

Student acceptance and application of peer assessment in a final year genetics undergraduate oral presentation

Verkade H, Bryson-Richardson RJ

J Peer Learning 6(1):1-18


In Vivo Wall Shear Measurements within the Developing Zebrafish Heart

Jamison RA, Samarage CR, Bryson-Richardson RJ, Fouras A

PLos One 8(10): e75722

Mutations in KLHL40 Are a Frequent Cause of Severe Autosomal-Recessive Nemaline Myopathy

Ravenscroft G, Miyatake S, Lehtokari VL, Todd EJ, Vornanen P, Yau KS, Hayashi YK, Miyake N, Tsurusaki Y, Doi H, Saitsu H, Osaka H, Yamashita S, Ohya T, Sakamoto Y, Koshimizu E, Imamura S, Yamashita M, Ogata K, Shiina M, Bryson-Richardson RJ, Vaz R, Ceyhan O, Brownstein CA, Swanson LC, Monnot S, Romero NB, Amthor H, Kresoje N, Sivadorai P, Kiraly-Borri C, Haliloglu G, Talim B, Orhan D, Kale G, Charles AK, Fabian VA, Davis MR, Lammens M, Sewry CA, Manzur A, Muntoni F, Clarke NF, North KN, Bertini E, Nevo Y, Willichowski E, Silberg IE, Topaloglu H, Beggs AH, Allcock RJ, Nishino I, Wallgren-Pettersson C, Matsumoto N, Laing NG.(2013)

Am J Hum Genet 93(1):6-18


Atlas of Zebrafish Development

Bryson-Richardson RJ, Berger S, Currie P

Academic Press, UK

Morphogenesis and Cell Fate Determination within the Adaxial Cell Equivalence Group of the Zebrafish Myotome

Nguyen-Chi ME, Bryson-Richardson RJ, Sonntag C, Hall TE, Gibson A, Sztal T, Chua W, Schilling TF, Currie PD

PLoS Genetics 8(10)e1003014

The Zebrafish Anatomy Portal: A novel integrated resource to facilitate zebrafish research

Salgado D, Marcelle C, Currie PD, Bryson-Richardson RJ

Dev Biol. S0012-1606(12)00490-3.

Characterization and investigation of zebrafish models of filamin-related myofibrillar myopathy

Ruparelia AA, Zhao M, Currie PD, Bryson-Richardson RJ

Hum Mol Genet. 21(18):4073-83.

Cardiac-phase filtering in intracardiac particle image velocimetry

Jamison RA, Fouras A, Bryson-Richardson RJ

J Biomed Opt 17(3).

Myofibrillar myopathies and the Z-disk associated proteins

Ruparelia A, Vaz RR, Bryson-Richardson RJ

chapter in Skeletal Muscle-From Myogenesis to Clinical Relations, eds Julianna Cseri, Intech, Croatia, pp. 317-358


Zebrafish prox1b mutants develop a lymphatic vasculature, and prox1b does not specifically mark lymphatic endothelial cells

Tao S, Witte M, Bryson-Richardson RJ, Currie PD, Hogan BM, Schulte-Merker S

PLoS One. 6(12):e28934.


The zebrafish dystrophic mutant softy maintains muscle fibre viability despite basement membrane rupture and muscle detachment

Jacoby AS, Busch-Nentwich E, Bryson-Richardson RJ, Hall TE, Berger J, Berger S, Sonntag C, Sachs C, Geisler R, Stemple DL, Currie PD

Development. 136(19):3367-76.


The Genetics of Vertebrate Myogenesis

Bryson-Richardson RJ, Currie PD

Nat Rev Genet. 9(8):632-46.


FishNet: an online database of zebrafish anatomy

Bryson-Richardson RJ, Berger S, Schilling TF, Hall TE, Cole NJ, Gibson AJ, Sharpe J, Currie PD.

BMC Biol. 5(1):34.

The zebrafish candyfloss mutant implicates extracellular matrix adhesion failure in laminin alpha2-deficient congenital muscular dystrophy

Hall TE, Bryson-Richardson RJ, Berger S, Jacoby AS, Cole NJ, Hollway GE, Berger J, Currie PD.

Proc Natl Acad Sci U S A. 104(17):7092-7.

Whole-somite rotation generates muscle progenitor cell compartments in the developing zebrafish embryo

Hollway GE, Bryson-Richardson RJ, Berger S, Cole NJ, Hall TE, Currie PD.

Dev Cell. 12(2):207-19.

The eIF4G-homolog p97 can activate translation independent of caspase cleavage

Nousch M, Reed V, Bryson-Richardson RJ, Currie PD, Preiss T.

RNA. 13(3):374-84.


Analysis of protein sequence and interaction data for candidate disease gene prediction

George RA, Liu JY, Feng LL, Bryson-Richardson RJ, Fatkin D, Wouters MA.

Nucleic Acids Res. 34(19):e130.


Myosin heavy chain expression in zebrafish and slow muscle composition

Bryson-Richardson RJ, Daggett DF, Cortes F, Neyt C, Keenan DG, Currie PD.

Dev Dyn. 233(3):1018-22.


Optical projection tomography for spatio-temporal analysis in the zebrafish

Bryson-Richardson RJ, Currie PD

Methods Cell Biol. 76:37-50.

Developmentally restricted actin-regulatory molecules control morphogenetic cell movements in the zebrafish gastrula

Daggett DF, Boyd CA, Gautier P, Bryson-Richardson RJ, Thisse C, Thisse B, Amacher SL, Currie PD. Curr Biol. 14(18):1632-8.

Met and Hgf signaling controls hypaxial muscle and lateral line development in the zebrafish

Haines L, Neyt C, Gautier P, Keenan DG, Bryson-Richardson RJ, Hollway GE, Cole NJ, Currie PD.

Development. 131(19):4857-69.

Large-scale analysis of gene structure in rhodopsin-like GPCRs: evidence for widespread loss of an ancient intron

Bryson-Richardson RJ, Logan DW, Currie PD, Jackson IJ.

Gene. 338(1):15-23.


Cadherin-mediated differential cell adhesion controls slow muscle cell migration in the developing zebrafish myotome

Cortes F, Daggett D, Bryson-Richardson RJ, Neyt C, Maule J, Gautier P, Hollway GE, Keenan D, Currie PD.

Dev Cell. 5(6):865-76.

Dystrophin is required for the formation of stable muscle in the zebrafish embryo  

Bassett DI, Bryson-Richardson RJ, Daggett DF, Gautier P, Keenan DG, Currie PD.

Development. 130(23) 5851-60.

Sequence characterization of teleost fish melanocortin receptors

Logan DW, Bryson-Richardson RJ, Taylor MS, Currie P, Jackson IJ.

Ann N Y Acad Sci. 994:319-30.

The structure and evolution of the melanocortin and MCH receptors in fish and mammals

Logan DW, Bryson-Richardson RJ, Pagan KE, Taylor MS, Currie PD, Jackson IJ.

Genomics. 81(2):184-91.

Citation information is available from Google Scholar